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Wine (see more at WineHQ)

Wine lets you run Windows software on other operating systems. With Wine, you can install and run these applications just like you would in Windows.

Wine is still under active development. Not every program works yet, however there are already several million people using Wine to run their software.

Running Windows Applications with Wine
winetricks
How to video tutorial...Installation and introduction to Wine.
How to video tutorial...Installing Windows runtime libraries and fonts with winetricks.
 Downloading and installing a windows based application and running in Wine.
Google Sketchup on LinuxHow to video tutorial...Download, install and run Google Sketchup in Wine.
Crossover
Using Wine as it's code base. Crossover offers even more to get your windows applications up and running.  Crossover homepage.  Examples of application you can get running using Crossover.
Crossover LinuxHow to video tutorial... Crossover Chromium (Googles codebase brower on Linux)
 
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